STI student David Brown published an STI research paper in January with some interesting ideas to prevent living off the land attacks with AppLocker. Living off the land attacks use existing Windows binaries instead of downloading specific attack tools. This post-compromise technique is very difficult to block. AppLocker isn’t really designed to block these attacks because AppLocker by default does allow standard Windows binaries to run.
Article Link: https://isc.sans.edu/diary/rss/26032